Summary: A modeling study of the role of tonic vs. phasic dopamine input
to the prefrontal cortex
Denis Sheynikhovich1
, Satoru Otani2
, Angelo Arleo1
1. CNRS-UPMC UMR7102, Univ. Paris 6, F-75005 Paris, France
2. INSERM-U952, CNRS-UMR7224, Univ. Paris 6, F-75005 Paris, France
ABSTRACT
This work presents a computational model of dopamine
(DA) influence on long-term potentiation (LTP) and
long-term depression (LTD) in the prefrontal cortex.
Distinct properties of the model are a DA-
concentration-dependent switch from depression to
potentiation during induction of plasticity, and an
inverted-U-shaped dependence of protein synthesis
threshold on the level of background DA. Protein
synthesis is responsible for maintenance and late phase
of LTP/LTD in the model. Our simulations suggest that
in order to comply with in vitro experimental data,
prefrontal synapses must contain a protein that is slowly

Source: Arleo, Angelo - Laboratory of Neurobiology of Adaptive Processes, Université Pierre-et-Marie-Curie, Paris 6

Collections: Biology and Medicine