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The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 2 417-427
 

Summary: Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 2 417-427
www.jem.org/cgi/doi/10.1084/jem.20092449
417
There are two well-characterized mammalian
DSB repair pathways. Homologous recombi-
nation accurately repairs post-replicative DSBs
via a long, homologous template from a sister
chromatid, whereas nonhomologous end join-
ing (C-NHEJ) fuses DSB ends that lack sub-
stantial junctional homology (Bassing and Alt,
2004). Thus, C-NHEJ is particularly important
during the G1 cell cycle phase when homolo-
gous templates from sister chromatids are not
available (Lieber et al., 2008). Studies of the
repair of RAG endonuclease-generated DSBs,
in the context of lymphocyte-specific V(D)J
recombination, were critical for elucidation of
C-NHEJ. In this context, V(D)J recombina-

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine