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Summary: Leading Opinion
Embryoid body morphology influences diffusive transport of inductive
biochemicals: A strategy for stem cell differentiationq
Eleftherios Sachlos, Debra T. Auguste*
School of Engineering and Applied Sciences, Harvard University, 29 Oxford Street, Cambridge, MA 02138, USA
a r t i c l e i n f o
Article history:
Received 10 July 2008
Accepted 20 August 2008
Available online 14 September 2008
Keywords:
Human embryonic stem cells
Embryoid bodies
Diffusion
Differentiation
Collagen
Extracellular matrix
a b s t r a c t
Differentiation of human embryonic stem (hES) cells into cells for regenerative medicine is often initiated
by embryoid body (EB) formation. EBs may be treated with soluble biochemicals such as cytokines,
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