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this hypothesis were obtained in mice deficient in parallel fiber LTD, which can learn to blink to a tone following
 

Summary: this hypothesis were obtained in mice deficient in parallel
fiber LTD, which can learn to blink to a tone following
classical conditioning but exhibit inaccurate blink timing
(De Zeeuw and Yeo, 2005). The two studies discussed
here provide the first firm physiological evidence for the
predicted forms of plasticity at the mossy fiber to deep
nuclear synapse. It is intriguing to speculate that the
LTP described by Pugh and Raman could participate in
acquisition of eyeblink conditioning, while the LTD de-
scribed by Zhang and Linden may play a role in extinc-
tion. Other forms of cerebellum-dependent learning, in-
cluding adaptation of the vestibulo-ocular reflex or of
reaching movements, are likely to rely on similar forms
of plasticity. Because so much is known about the down-
stream effects of deepnucleus neuronal activity, thecon-
sequences of experimental manipulations that specifi-
cally enhance or abolish each type of synaptic plasticity
can be assessed in behaving animals, providing one of
the rare opportunities to forge a clear link between phys-
iological plasticity and behavioral learning in vertebrates.

  

Source: Andersen, Richard - Division of Biology, California Institute of Technology
Graziano, Michael - Department of Psychology, Princeton University

 

Collections: Biology and Medicine