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Molecular Biology of the Cell Vol. 13, 830846, March 2002
 

Summary: Molecular Biology of the Cell
Vol. 13, 830846, March 2002
Stretch-regulated Exocytosis/Endocytosis in Bladder
Umbrella Cells
Steven T. Truschel,*
Edward Wang,*
Wily G. Ruiz,* Som-Ming Leung,* Raul
Rojas,* John Lavelle,* Mark Zeidel,* David Stoffer,
and Gerard Apodaca*
*Renal-Electrolyte Division, Department of Medicine, Laboratory of Epithelial Cell Biology, and
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261;
and
Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania 15260
Submitted September 4, 2001; Revised November 13, 2001; Accepted December 5, 2001
Monitoring Editor: Howard Riezman
The epithelium of the urinary bladder must maintain a highly impermeable barrier despite large
variations in urine volume during bladder filling and voiding. To study how the epithelium
accommodates these volume changes, we mounted bladder tissue in modified Ussing chambers
and subjected the tissue to mechanical stretch. Stretching the tissue for 5 h resulted in a 50%
increase in lumenal surface area (from 2900 to 4300 m2

  

Source: Apodaca, Gerard - Departments of Medicine & Cell Biology and Physiology, University of Pittsburgh

 

Collections: Biology and Medicine