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Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression

Summary: Dysbindin regulates hippocampal LTP by controlling
NMDA receptor surface expression
Tina Tze-Tsang Tanga,b
, Feng Yangc
, Bo-Shiun Chena
, Yuan Lud
, Yuanyuan Jic
, Katherine W. Rochea,1
, and Bai Luc,d,1
aReceptor Biology Section, National Institute of Neurological Disorders and Stroke, cSection on Neural Development and Plasticity, National Institute of
Child Health and Human Development, and dGene, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health,
Bethesda, MD 20892-3714; and bMedical Research Council Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical
Sciences, Bristol BS8 1TD, United Kingdom
Edited by Richard L. Huganir, Johns Hopkins University School of Medicine, Baltimore, MD, and approved October 16, 2009 (received for review
September 13, 2009)
Abnormalities in NMDA receptor (NMDAR) function have been
implicated in schizophrenia. Here, we show that dysbindin, a
schizophrenia-susceptibility gene widely expressed in the fore-
brain, controls the surface expression of NMDARs in a subunit-
specific manner. Imaging analyses revealed a marked increase in


Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago


Collections: Biology and Medicine