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Regeneration in Planaria Phillip A Newmark,Carnegie Institution of Washington, Baltimore, Maryland, USA
 

Summary: Regeneration in Planaria
Phillip A Newmark,Carnegie Institution of Washington, Baltimore, Maryland, USA
Alejandro Sa´nchez Alvarado, Carnegie Institution of Washington, Baltimore, Maryland,
USA
Planarians possess remarkable regenerative abilities enabling them to replace parts of the
body removed by amputation or naturally occurring fission. The regenerative process is
mediated by the formation and eventual differentiation of a specialized structure known as
the regeneration blastema.
Introduction
In metazoans, regeneration of lost body parts requiring the
formation of a blastema is known as epimorphic regenera-
tion. A blastema is composed primarily of two cell
populations: an outer cell layer or ectoderm, derived from
the epidermis that covers the wound surface after amputa-
tion/fission; and mesenchymal cells that proliferate and
accumulate beneath this wound epidermis, eventually
differentiating into the lost body parts (Figure 1). Even
though the architecture of both planarian and vertebrate
blastemas is the same, the mechanism of blastema
formation in planarians differs from that of vertebrates

  

Source: Alvarado, Alejandro Sánchez - Department of Neurobiology and Anatomy, University of Utah
Newmark, Phillip A. - Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign
Selvin, Paul R. - Department of Physics, University of Illinois at Urbana-Champaign

 

Collections: Biology and Medicine; Materials Science; Physics