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A model for glioma cell migration on collagen and astrocytes

Summary: A model for glioma cell migration
on collagen and astrocytes
M. Aubert1,*, M. Badoual1
, C. Christov2
and B. Grammaticos1
IMNC, UniversiteŽs ParisVII-Paris XI, CNRS, UMR 8165, Ba^timent104,91406 Orsay, France
Plate-forme d'Imagerie Cellulaire et Tissulaire de l'IFR10,
Institut Mondor de MeŽdecine MoleŽculaire, France and INSERM E0011,
FaculteŽ de MeŽdecine, UniversiteŽ Paris XII, 94000 CreŽteil, France
We present a model for the migration of glioma cells on substrates of collagen and astrocytes.
The model is based on a cellular automaton where the various dynamical effects are
introduced through adequate evolution rules. Using our model, we investigate the role of
homotype and heterotype gap junction communication and show that it is possible to
reproduce the corresponding experimental migration patterns. In particular, we confirm the
experimental findings that inhibition of homotype gap junctions favours migration while
heterotype inhibition hinders it. Moreover, the effect of heterotype gap junction inhibition
dominates that of homotype inhibition.
Keywords: tumour cells; gap junction; migration properties


Source: Aubert, Marine - Department of Mathematics, University of Dundee


Collections: Mathematics