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BioMed Central Page 1 of 12
 

Summary: BioMed Central
Page 1 of 12
(page number not for citation purposes)
BMC Developmental Biology
Open AccessResearch article
The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin
disrupts morphogenesis of the rat pre-implantation embryo
Karla J Hutt1, Zhanquan Shi2, David F Albertini1,3 and Brian K Petroff*2
Address: 1The Center for Reproductive Sciences, Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901
Rainbow Boulevard, Kansas City, KS 66160, USA, 2Department of Internal Medicine, University of Kansas Medical Center, 3901 Rainbow
Boulevard, Kansas City, KS 66160, USA and 3Marine Biological Laboratory, Woods Hole, MA 02543, USA
Email: Karla J Hutt - huttx006@umn.edu; Zhanquan Shi - shizq2001@yahoo.com; David F Albertini - dalbertini@kumc.edu;
Brian K Petroff* - bpetroff@kumc.edu
* Corresponding author
Abstract
Background: Environmental toxicants, whose actions are often mediated through the aryl
hydrocarbon receptor (AhR) pathway, pose risks to the health and well-being of exposed species,
including humans. Of particular concern are exposures during the earliest stages of development
that while failing to abrogate embryogenesis, may have long term effects on newborns or adults.
The purpose of this study was to evaluate the effect of maternal exposure to the AhR-specific ligand

  

Source: Albertini, David - Center for Reproductive Sciences, University of Kansas

 

Collections: Biology and Medicine