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Temporal Global Expression Data Reveal Known and Novel Salicylate-Impacted Processes and Regulators

Summary: Temporal Global Expression Data Reveal Known and
Novel Salicylate-Impacted Processes and Regulators
Mediating Powdery Mildew Growth and Reproduction
on Arabidopsis1[W][OA]
Divya Chandran, Yu Chuan Tai2
, Gregory Hather, Julia Dewdney, Carine Denoux, Diane G. Burgess,
Frederick M. Ausubel, Terence P. Speed, and Mary C. Wildermuth*
Department of Plant and Microbial Biology (D.C., G.H., D.G.B., M.C.W.), Division of Biostatistics (Y.C.T.), and
Department of Statistics (G.H., T.P.S.), University of California, Berkeley, California 94720; Department
of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114 (J.D., C.D., F.M.A.);
and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114 (J.D., C.D., F.M.A.)
Salicylic acid (SA) is a critical mediator of plant innate immunity. It plays an important role in limiting the growth and
reproduction of the virulent powdery mildew (PM) Golovinomyces orontii on Arabidopsis (Arabidopsis thaliana). To investigate
this later phase of the PM interaction and the role played by SA, we performed replicated global expression profiling for wild-
type and SA biosynthetic mutant isochorismate synthase1 (ics1) Arabidopsis from 0 to 7 d after infection. We found that ICS1-
impacted genes constitute 3.8% of profiled genes, with known molecular markers of Arabidopsis defense ranked very highly
by the multivariate empirical Bayes statistic (T2
statistic). Functional analyses of T2
-selected genes identified statistically
significant PM-impacted processes, including photosynthesis, cell wall modification, and alkaloid metabolism, that are ICS1


Source: Ausubel, Frederick M. - Department of Genetics, Harvard University


Collections: Biology and Medicine