Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Developmental Cell The Kinesin-8 Motor Kif18A Suppresses Kinetochore
 

Summary: Developmental Cell
Article
The Kinesin-8 Motor Kif18A Suppresses Kinetochore
Movements to Control Mitotic Chromosome Alignment
Jason Stumpff,1 George von Dassow,2 Michael Wagenbach,1 Charles Asbury,1 and Linda Wordeman1,*
1Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA
2Center for Cell Dynamics, Friday Harbor Laboratories, University of Washington, Friday Harbor, WA 98250, USA
*Correspondence: worde@u.washington.edu
DOI 10.1016/j.devcel.2007.11.014
SUMMARY
During vertebrate cell division, chromosomes oscil-
late with periods of smooth motion interrupted by
abrupt reversals in direction. These oscillations
must be spatially constrained in order to align and
segregate chromosomes with high fidelity, but the
molecular mechanism for this activity is uncertain.
We report here that the human kinesin-8 Kif18A has
a primary role in the control of chromosome oscilla-
tions. Kif18A accumulates as a gradient on kineto-
chore microtubules in a manner dependent on its

  

Source: Asbury, Chip - Department of Physiology and Biophysics, University of Washington at Seattle

 

Collections: Biology and Medicine