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IOP PUBLISHING JOURNAL OF MICROMECHANICS AND MICROENGINEERING J. Micromech. Microeng. 18 (2008) 065020 (10pp) doi:10.1088/0960-1317/18/6/065020
 

Summary: IOP PUBLISHING JOURNAL OF MICROMECHANICS AND MICROENGINEERING
J. Micromech. Microeng. 18 (2008) 065020 (10pp) doi:10.1088/0960-1317/18/6/065020
Drop on demand in a microfluidic chip
Jie Xu and Daniel Attinger
Laboratory for Microscale Transport Phenomena, Department of Mechanical Engineering,
Columbia University, New York, NY 10027, USA
Received 9 November 2007, in final form 22 April 2008
Published 19 May 2008
Online at stacks.iop.org/JMM/18/065020
Abstract
In this work, we introduce the novel technique of in-chip drop on demand, which consists in
dispensing picoliter to nanoliter drops on demand directly in the liquid-filled channels of a
polymer microfluidic chip, at frequencies up to 2.5 kHz and with precise volume control. The
technique involves a PDMS chip with one or several microliter-size chambers driven by
piezoelectric actuators. Individual aqueous microdrops are dispensed from the chamber to a
main transport channel filled with an immiscible fluid, in a process analogous to atmospheric
drop on demand dispensing. In this paper, the drop formation process is characterized with
respect to critical dispense parameters such as the shape and duration of the driving pulse, and
the size of both the fluid chamber and the nozzle. Several features of the in-chip drop on
demand technique with direct relevance to lab-on-a-chip applications are presented and

  

Source: Attinger, Daniel - Department of Mechanical Engineering, Columbia University

 

Collections: Engineering