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Neuroscience Letters 407 (2006) 176181 Expression of IL-1 in supraspinal brain regions
 

Summary: Neuroscience Letters 407 (2006) 176181
Expression of IL-1 in supraspinal brain regions
in rats with neuropathic pain
A. Vania Apkariana,, Simona Lavarelloa, Anke Randolfb, Hector H. Berraa,
Dante R. Chialvoa, Hugo O. Besedovskyb, Adriana del Reyb
a Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave., Chicago, IL 60611, USA
b Institute of Normal and Pathological Physiology, University of Marburg, Marburg, Germany
Received 14 July 2006; received in revised form 10 August 2006; accepted 15 August 2006
Abstract
We examined mRNA expression of the pro-inflammatory cytokine IL-1 in the brainstem, thalamus, and prefrontal cortex in two rat models of
neuropathic pain. Rats received a neuropathic injury: spared nerve injury (SNI) or chronic constriction injury (CCI), sham injury, or were minimally
handled (control). Neuropathic pain-like behavior was monitored by tracking tactile thresholds. SNI-injured animals showed a robust decrease in
tactile thresholds of the injured foot, while CCI-injured animals did not show tactile threshold changes. Ten or 24 days after nerve injury, IL-1
gene expression in the brain was determined by RT-PCR. IL-1 expression changes were observed mainly at 10 days after injury in the SNI
animals, contralateral to the injury side, with increased expression in the brainstem and prefrontal cortex. The results indicate that neuro-immune
activation in neuropathic pain conditions includes supraspinal brain regions, suggesting cytokine modulation of supraspinal circuitry of pain in
neuropathic conditions.
2006 Elsevier Ireland Ltd. All rights reserved.
Keywords: Cytokines; Chronic pain; Brainstem; Thalamus; Prefrontal cortex
There is now convincing evidence that cytokine expression in the

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine