Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit
 

Summary: Division of labor among distinct subtypes
of inhibitory neurons in a cortical microcircuit
of working memory
X.-J. Wang*
, J. Tegne´r*
, C. Constantinidis§¶
, and P. S. Goldman-Rakic§
*Center for Complex Systems, Brandeis University, Waltham, MA 02254; Department of Physics, Linko¨ pings Institute of Technology, S-581 83 Linko¨ ping,
Sweden; §Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510; and ¶Wake Forest University School of
Medicine, Department of Neurobiology and Anatomy, Winston­Salem, NC 27157-1010
Edited by Marcus E. Raichle, Washington University School of Medicine, St. Louis, MO, and approved November 13, 2003 (received for review
August 20, 2003)
A conspicuous feature of cortical organization is the wide diversity of
inhibitory interneurons; their differential computational functions
remain unclear. Here we propose a local cortical circuit in which three
major subtypes of interneurons play distinct roles. In a model de-
signed for spatial working memory, stimulus tuning of persistent
activity arises from the concerted action of widespread inhibition
mediated by perisoma-targeting (parvalbumin-containing) interneu-
rons and localized disinhibition of pyramidal cells via interneuron-

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra
Wang, Xiao-Jing - Kavli Institute for Neuroscience & Department of Neurobiology, Yale University

 

Collections: Biology and Medicine; Computer Technologies and Information Sciences