Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17p
 

Summary: Mer1p is a modular splicing factor whose function
depends on the conserved U2 snRNP protein Snu17p
Marc Spingola1,2,*, Javier Armisen2
and Manuel Ares Jr1
1
Center for the Molecular Biology of RNA, Sinsheimer Laboratories, University of California, Santa Cruz,
Santa Cruz, CA 95064, USA and 2
Department of Biology, University of Missouri, Saint Louis, 8001 Natural Bridge
Road, Saint Louis, MO 63121, USA
Received December 19, 2003; Revised and Accepted January 22, 2004
ABSTRACT
Mer1p activates the splicing of at least three
pre-mRNAs (AMA1, MER2, MER3) during meiosis in
the yeast Saccharomyces cerevisiae. We demon-
strate that enhancer recognition by Mer1p is separ-
able from Mer1p splicing activation. The C-terminal
KH-type RNA-binding domain of Mer1p recognizes
introns that contain the Mer1p splicing enhancer,
while the N-terminal domain interacts with the
spliceosome and activates splicing. Prior studies

  

Source: Ares Jr., Manny - Department of Molecular, Cell, and Developmental Biology, University of California at Santa Cruz

 

Collections: Biology and Medicine