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Summary: UNCORRECTEDPROOF
1 Role of orexin/hypocretin in reward-seeking and addiction: Implications for obesity
2 Angie M. Cason, Rachel J. Smith, Pouya Tahsili-Fahadan, David E. Moorman,
3 Gregory C. Sartor, Gary Aston-Jones
4 Department of Neurosciences, Medical University of South Carolina, Basic Science Building 403, 173 Ashley Avenue, MSC 510, Charleston, SC, 29425, USA
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a b s t r a c ta r t i c l e i n f o
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8 Available online xxxx
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12 Keywords:
13 Orexin
14 Addiction
15 Obesity
16 Reward-based feeding
17 Palatable food
18 Conditioned stimuli
19Orexins (also named hypocretins) are recently discovered neuropeptides made exclusively in the
20hypothalamus. Recent studies have shown that orexin cells located specifically in lateral hypothalamus
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