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J Comput Neurosci DOI 10.1007/s10827-006-0010-x

Summary: J Comput Neurosci
DOI 10.1007/s10827-006-0010-x
Sparse cerebellar innervation can morph the dynamics of a model
oculomotor neural integrator
Thomas J. Anastasio Yash P. Gad
Received: 19 June 2006 / Revised: 2 October 2006 / Accepted: 6 October 2006
C Springer Science + Business Media, LLC 2006
Abstract The oculomotor integrator is a brainstem neural
network that converts velocity signals into the position com-
mands necessary for eye-movement control. The cerebellum
can independently adjust the amplitude of eye-movement
commands and the temporal characteristics of neural inte-
gration, but the percentage of integrator neurons that receive
cerebellar input is very small. Adaptive dynamic systems
models, configured using the genetic algorithm, show how
sparse cerebellar inputs could morph the dynamics of the
oculomotor integrator and independently adjust its overall
response amplitude and time course. Dynamic morphing
involves an interplay of opposites, in which some model
Purkinje cells exert positive feedback on the network, while


Source: Anastasio, Thomas J. - Beckman Institute for Advanced Science and Technology & Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign


Collections: Biology and Medicine