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Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs

Summary: Discovery of antiandrogen activity of nonsteroidal
scaffolds of marketed drugs
W. H. Bisson*, A. V. Cheltsov*, N. Bruey-Sedano
, B. Lin
, J. Chen
, N. Goldberger
, L. T. May§¶
, A. Christopoulos¶
J. T. Dalton
, P. M. Sexton¶
, X.-K. Zhang
, and R. Abagyan*
*Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037; Department of Oncodevelopmental Biology, The Burnham Institute,
La Jolla, CA 92037; College of Pharmacy, Ohio State University, Columbus, OH 43210; §Department of Pharmacology, University of Melbourne, Victoria
3010, Australia; and ¶Drug Discovery Biology Laboratory, Department of Pharmacology, Monash University, Victoria 3800, Australia
Edited by Etienne-Emile Baulieu, Colle`ge de France, Le Kremlin-Bicetre Cedex, France, and approved June 6, 2007 (received for review November 2, 2006)
Finding good drug leads de novo from large chemical libraries, real
or virtual, is not an easy task. High-throughput screening is often
plagued by low hit rates and many leads that are toxic or exhibit


Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego


Collections: Biology and Medicine