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Summary: J Neural Transm (2002) 109: 1533
Multi-chemical networking profile of the living human brain:
potential relevance to molecular studies of cognition and behavior
in normal and diseased brain
I. D. Grachev1,2
and A. V. Apkarian3
Departments of 1
Radiology and
2
Neuroscience & Physiology, SUNY Upstate Medical University, Syracuse, NY, and
3
Department of Physiology, Northwestern University Medical School,
Chicago, IL, USA
Received July 18, 2001; accepted September 6, 2001
Summary. Anatomical, electrophysiological and functional neuroimaging
studies show that the human brain is a complex network, where cortico-
cortical and thalamo-cortical connections are organized in a specific pattern
giving rise to brain function. In our recent studies we found that chemical
connectivity between brain regions might be changed in different conditions
(e.g. aging, chronic pain, cognitive interference). The elucidation of properties
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