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TheJournalofGeneralPhysiology A RT I C L E
 

Summary: TheJournalofGeneralPhysiology
A RT I C L E
J. Gen. Physiol. The Rockefeller University Press $30.00
Volume 131 Number 2 February 2008 137146
http://www.jgp.org/cgi/doi/10.1085/jgp.200709896
137
Correspondence to Myles Akabas: makabas@aecom.yu.edu
I N T R O D U C T I O N
At fast chemical synapses, ligand-gated ion channels
(LGICs) transduce chemical signals into electrical sig-
nals. Cys-loop receptors, a major superfamily of LGICs,
include receptors for acetylcholine (nAChR), -amino-
butyric acid (GABAAR, GABACR), glycine (GlyR), and
serotonin (5-hydroxytryptamine type 3, 5-HT3). These
channels are either cation (nAChR, 5-HT3) or anion se-
lective (GABAAR, GABACR, GlyR) (Macdonald and Olsen,
1994; Karlin, 2002; Lester et al., 2004). Cys-loop recep-
tors are pentameric assemblies of homologous subunits
arranged pseudosymmetrically around the central ion-
conducting pore. All Cys-loop receptor subunits have

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine