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MOLECULAR AND CELLULAR BIOLOGY, 0270-7306/99/$04.00 0
 

Summary: MOLECULAR AND CELLULAR BIOLOGY,
0270-7306/99/$04.00 0
Apr. 1999, p. 28352845 Vol. 19, No. 4
Copyright 1999, American Society for Microbiology. All Rights Reserved.
MOT1 Can Activate Basal Transcription In Vitro by Regulating
the Distribution of TATA Binding Protein between
Promoter and Nonpromoter Sites
TAMARA A. MULDROW,1
ALLYSON M. CAMPBELL,2
P. ANTHONY WEIL,2
AND DAVID T. AUBLE1
*
Department of Biochemistry and Molecular Genetics, University of Virginia Health Science Center,
Charlottesville, Virginia 22908,1
and Department of Molecular Physiology and Biophysics,
Vanderbilt University School of Medicine, Nashville, Tennessee 37232-06152
Received 10 December 1998/Accepted 13 January 1999
MOT1 is an ATPase which can dissociate TATA binding protein (TBP)-DNA complexes in a reaction re-
quiring ATP hydrolysis. Consistent with this observation, MOT1 can repress basal transcription in vitro.
Paradoxically, however, some genes, such as HIS4, appear to require MOT1 as an activator of transcription in

  

Source: Auble, David - Department of Biochemistry and Molecular Genetics, University of Virginia

 

Collections: Biology and Medicine