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Phil. Trans. R. Soc. A (2010) 368, 439454 doi:10.1098/rsta.2009.0242
 

Summary: Phil. Trans. R. Soc. A (2010) 368, 439­454
doi:10.1098/rsta.2009.0242
Controlling biological networks by
time-delayed signals
BY GÁBOR OROSZ1,*, JEFF MOEHLIS1 AND RICHARD M. MURRAY2
1Department of Mechanical Engineering, University of California,
Santa Barbara, CA 93106, USA
2Control and Dynamical Systems, California Institute of Technology,
Pasadena, CA 91125, USA
This paper describes the use of time-delayed feedback to regulate the behaviour of
biological networks. The general ideas on specific transcriptional regulatory and neural
networks are demonstrated. It is shown that robust yet tunable controllers can be
constructed that provide the biological systems with model-engineered inputs. The results
indicate that time delay modulation may serve as an efficient biocompatible control tool.
Keywords: time delay; control; gene regulatory network; neural network
1. Introduction
A common rule of thumb in engineering is that time delays can cause undesired
oscillations. For example, the use of high-frequency digital controllers (which
introduce tiny delays into the control loops) can result in low-frequency vibrations
in robotic systems (Stépán 2001). In most cases, engineers are able to overcome

  

Source: Awtar, Shorya - Department of Mechanical Engineering, University of Michigan

 

Collections: Engineering