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Summary: Article
The Rockefeller University Press $30.00
J. Exp. Med. Vol. 207 No. 11 2331-2341
www.jem.org/cgi/doi/10.1084/jem.20101074
2331
Regulatory T (T reg) cells are a subset of lym-
phocytes that play a key role in maintaining
immune homeostasis by virtue of their abil-
ity to actively suppress the immune response
(Sakaguchi et al., 2006; Zheng and Rudensky,
2007; Shevach, 2009). Natural T reg cells that
emerge from the thymus with self-specificity
limit activation and expansion of autoreactive
T cells in the periphery, whereas inducible T
(iT) reg cells derive from conventional T cells
that are antigen stimulated in the presence of
mediators such as TGF-, IL-10, and retinoic
acid (Hawrylowicz and O'Garra, 2005; Mucida
et al., 2007; Curotto de Lafaille and Lafaille,
2009). In some systems, iT reg cells may initi-
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