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Introduction T-box genes are a large family of transcriptional regulators
 

Summary: 2373
Introduction
T-box genes are a large family of transcriptional regulators
unified by a conserved DNA binding, or T, domain that have
important, yet diverse roles in patterning animal development
(reviewed by Papaioannou, 2001). Mouse mutations in T-box
genes such as Brachyury and Tbx6 are associated with
notochord and mesoderm, or neural tube defects, respectively
(Herrmann, 1995; Chapman and Papaioannou, 1998), and
chick Tbx4 and Tbx5 have roles in limb specification (reviewed
by Simon, 1999). In Xenopus, Brachyury (Xbra) is required for
the development of mesoderm (Conlon et al., 1996), while
VegT is required for induction of mesoderm and endoderm
(Kofron et al., 1999; Zhang et al., 1998). The Drosophila
Brachyury homologue brachyenteron (byn), or Trg, functions
in the formation of hindgut and posterior mesoderm (Kispert
et al., 1994; Singer et al., 1996; Kusch and Reuter, 1999), while
optomotor blind (omb) is necessary for the development of
anterior sensory structures such as the eye (Pflugfelder and
Heisenberg, 1995). In addition, several T-box genes are

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine