Summary: Molecular Cell, Vol. 14, 221­231, April 23, 2004, Copyright 2004 by Cell Press
Minimal Conditions for Exonization of Intronic
Sequences: 5 Splice Site Formation in Alu Exons
tor to proteome diversification (Brett et al., 2002; Grave-
ley, 2001). Bioinformatic analyses indicate that 35%­
74% of all human genes participate in alternative
Rotem Sorek,1,2,5
Galit Lev-Maor,1,5
Mika Reznik,1,5
Tal Dagan,3
Frida Belinky,3
Dan Graur,4
and Gil Ast1,
*
splicing, which contributes significantly to human pro-1
Department of Human Genetics and
teome complexity and explains the numerical disparityMolecular Medicine
between genes and proteins (Black, 2000; Johnson etSackler Faculty of Medicine
al., 2003; Modrek and Lee, 2002). Alternative splicing isTel Aviv University
often regulated according to cell type, developmentalRamat Aviv 69978

Source: Ast, Gil - Department of Molecular Genetics and Biochemistry, Tel Aviv University
Huchon, Dorothée - http://www.tau.ac.il/lifesci/departments/zoology/members.html
Sorek, Rotem - Department of Molecular Genetics, Weizmann Institute of Science

Collections: Biology and Medicine; Environmental Sciences and Ecology