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Chromosomal location targets different MYC family gene members for oncogenic translocations
 

Summary: Chromosomal location targets different MYC family
gene members for oncogenic translocations
Monica Gostissa1
, Sheila Ranganath1
, Julia M. Bianco, and Frederick W. Alt2
The Howard Hughes Medical Institute, Children's Hospital Boston, Immune Disease Institute, and Department of Genetics, Harvard Medical School,
300 Longwood Avenue, Boston, MA 02115
Contributed by Frederick W. Alt, December 16, 2008 (sent for review December 5, 2008)
The MYC family of cellular oncogenes includes c-Myc, N-myc, and
L-myc, which encode transcriptional regulators involved in the
control of cell proliferation and death. Accordingly, these genes
become aberrantly activated and expressed in specific types of
cancers. For example, c-Myc translocations occur frequently in
human B lymphoid tumors, while N-myc gene amplification is
frequent in human neuroblastomas. The observed association
between aberrations in particular MYC family genes and specific
subsets of malignancies might reflect, at least in part, tissue-
specific differences in expression or function of a given MYC gene.
Since c-Myc and N-myc share substantial functional redundancy,
another factor that could influence tumor-specific gene activation

  

Source: Alt,, Frederick - Immune Disease Institute, Harvard University

 

Collections: Biology and Medicine