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Drosophila Pacemaker Neurons Require G Protein Signaling and GABAergic Inputs to Generate
 

Summary: Neuron
Article
Drosophila Pacemaker Neurons Require G Protein
Signaling and GABAergic Inputs to Generate
Twenty-Four Hour Behavioral Rhythms
David Dahdal,1 David C. Reeves,2,3 Marc Ruben,1 Myles H. Akabas,2 and Justin Blau1,*
1Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
2Department of Physiology and Biophysics and Department of Neuroscience, Albert Einstein College of Medicine of Yeshiva University,
Bronx, NY 10461, USA
3Present address: ARMGO Pharma Inc., 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
*Correspondence: justin.blau@nyu.edu
DOI 10.1016/j.neuron.2010.11.017
SUMMARY
Intercellular signaling is important for accurate circa-
dian rhythms. In Drosophila, the small ventral lateral
neurons (s-LNvs) are the dominant pacemaker
neurons and set the pace of most other clock neurons
in constant darkness. Here we show that two distinct
G protein signaling pathways are required in LNvs for
24 hr rhythms. Reducing signaling in LNvs via the G

  

Source: Akabas, Myles - Department of Physiology and Biophysics, Albert Einstein College of Medicine, Yeshiva University

 

Collections: Biology and Medicine