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Preparation of Human Metabolites of Propranolol Using Laboratory-Evolved
 

Summary: Preparation of Human Metabolites of
Propranolol Using Laboratory-Evolved
Bacterial Cytochromes P450
Christopher R. Otey,1
Geethani Bandara,2
James Lalonde,2
Katsuyuki Takahashi,2
Frances H. Arnold1,2
1
Biochemistry and Molecular Biophysics, California Institute of Technology,
Mail code 210-41, Pasadena, California 91125
2
Division of Chemistry and Chemical Engineering, California Institute of Technology,
Mail code 210-41, Pasadena, California 91125; telephone: (626) 395 4162;
fax: (626) 568-8743; e-mail: frances@cheme.caltech.edu
Received 27 June 2005; accepted 31 August 2005
DOI: 10.1002/bit.20744
Abstract: Testing the toxicities and biological activities of
the human metabolites of drugs is important for devel-
opment of safe and effective pharmaceuticals. Producing

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine