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Using haplotype blocks to map human complex trait loci
 

Summary: Using haplotype blocks to map human
complex trait loci
Lon R. Cardon1
and Gonc¸alo R. Abecasis2
1
Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
2
Department of Biostatistics, University of Michigan, Center for Statistical Genetics, 1420 Washington Heights,
University of Michigan Ann Arbor, MI 48109-2029, Michigan, USA
Understanding of linkage disequilibrium (LD) in human
populations could facilitate the discovery of genes that
influence complex human diseases. The `HapMap' pro-
ject is now underway to characterize patterns of LD in
the human genome. A pilot study showed `haplotype
blocks' in 51 regions scattered throughout the genome.
These intriguing results raise important questions
about the nature of recombination, and highlight prac-
tical issues of marker collection, the influence of stat-
istical modelling on apparent block structure, and the
levels of genotyping necessary for studies of common

  

Source: Abecasis, Goncalo - Department of Biostatistics, University of Michigan

 

Collections: Biology and Medicine; Mathematics