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Molecular Biology of the Cell Vol. 15, 11601171, March 2004

Summary: Molecular Biology of the Cell
Vol. 15, 11601171, March 2004
Meiosis-specific Failure of Cell Cycle Progression in
Fission Yeast by Mutation of a Conserved -Tubulin
Janet L. Paluh,*
Alison N. Killilea,
H. William Detrich, 3rd,
Kenneth H. Downing
*Department of Biology, Boston College, Chestnut Hill, Massachusetts 02467;
Life Sciences Division,
Lawrence Berkeley National Laboratory, Berkeley, California 94720; and
Department of Biology,
Northeastern University, Boston, Massachusetts 02115
Submitted June 11, 2003; Revised October 15, 2003; Accepted November 5, 2003
Monitoring Editor: Tim Stearns
The microtubule cytoskeleton is involved in regulation of cell morphology, differentiation, and cell cycle progression.
Precisely controlled dynamic properties are required for these microtubule functions. To better understand how tubulin's
dynamics are embedded in its primary sequence, we investigated in vivo the consequences of altering a single, highly


Source: Ayers, Joseph - Marine Science Center & Department of Biology, Northeastern University


Collections: Engineering