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Copyright 2005 by the Genetics Society of America DOI: 10.1534/genetics.104.032250
 

Summary: Copyright © 2005 by the Genetics Society of America
DOI: 10.1534/genetics.104.032250
Genomic Heterogeneity of Background Substitutional Patterns
in Drosophila melanogaster
Nadia D. Singh,*,1
Peter F. Arndt
and Dmitri A. Petrov*
*Department of Biological Sciences, Stanford University, Stanford, California 94305
and
Max Planck Institute for Molecular Genetics, 14195 Berlin, Germany
Manuscript received June 15, 2004
Accepted for publication October 28, 2004
ABSTRACT
Mutation is the underlying force that provides the variation upon which evolutionary forces can act. It
is important to understand how mutation rates vary within genomes and how the probabilities of fixation
of new mutations vary as well. If substitutional processes across the genome are heterogeneous, then examining
patterns of coding sequence evolution without taking these underlying variations into account may be mis-
leading. Here we present the first rigorous test of substitution rate heterogeneity in the Drosophila melanogaster
genome using almost 1500 nonfunctional fragments of the transposable element DNAREP1_DM. Not only
do our analyses suggest that substitutional patterns in heterochromatic and euchromatic sequences are

  

Source: Arndt, Peter - Max-Planck-Institut für molekulare Genetik
Petrov, Dmitri - Department of Biology, Stanford University
Spang, Rainer - Computational Molecular Biology Group, Max-Planck-Institut für molekulare Genetik

 

Collections: Biology and Medicine; Biotechnology; Computer Technologies and Information Sciences; Physics