Summary: mRNA stability and the unfolding of gene expression
in the long-period yeast metabolic cycle
, M. Zampieri
, L. Farina
and C. Altafini
SISSA, via Beirut 4, 34014 Trieste, Italy
Universita' degli Studi di Roma "La Sapienza",
via Ariosto 25, 00185 Roma, Italy
January 8, 2009
Background: In yeast, genome-wide periodic patterns associated with energy-metabolic
oscillations have been shown recently for both short (approx. 40 min) and long (approx.
300 min) periods.
Results: The dynamical regulation due to mRNA stability is shown to be an important
aspect of the genome-wide coordination of the long-period yeast metabolic cycle described
in . It is shown that for periodic genes, arranged in classes according either to expression
profile or to function, the pulses of mRNA abundance have phase and width which are
directly proportional to the corresponding turnover rates.
Conclusion: The cascade of events occurring during the yeast metabolic cycle (and their