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482 Research Paper CDC-42 controls early cell polarity and spindle orientation
 

Summary: 482 Research Paper
CDC-42 controls early cell polarity and spindle orientation
in C. elegans
Monica Gotta, Mary C. Abraham and Julie Ahringer
Background: Generation of asymmetry in the one-cell embryo of C. elegans Address: Wellcome/CRC Institute, Tennis Court
Road, Cambridge CB2 1QR, UK.establishes the anterior­posterior axis (A-P), and is necessary for the
proper identity of early blastomeres. Conserved PAR proteins are
Correspondence: Julie Ahringer
asymmetrically distributed and are required for the generation of this early
E-mail: jaa@mole.bio.cam.ac.uk
asymmetry. The small G protein Cdc42 is a key regulator of polarity in other
systems, and recently it has been shown to interact with the mammalian Received: 8 January 2001
homolog of PAR-6. The function of Cdc42 in C. elegans had not yet been Revised: 2 February 2001
Accepted: 21 February 2001investigated, however.
Published: 3 April 2001Results: Here, we show that C. elegans cdc-42 plays an essential role in
the polarity of the one-cell embryo and the proper localization of PAR
Current Biology 2001, 11:482­488
proteins. Inhibition of cdc-42 using RNA interference results in embryos
with a phenotype that is nearly identical to par-3, par-6, and pkc-3 mutants,
0960-9822/01/$ ­ see front matter

  

Source: Ahringe, Julie - Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge

 

Collections: Biology and Medicine