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Copyright 2002 by the Genetics Society of America Maximal Power Tests for Detecting Defects in Meiotic Recombination
 

Summary: Copyright 2002 by the Genetics Society of America
Maximal Power Tests for Detecting Defects in Meiotic Recombination
Thomas I. Milac,*,
Frederick R. Adler,
and Gerald R. Smith**,1
*Department of Applied Mathematics, University of Washington, Seattle, Washington 98195-2420,
The Genome Center, Department of
Medicine, University of Washington, Seattle, Washington 98195-2145,
Department of Mathematics, University of Utah,
Salt Lake City, Utah 84112,
Department of Biology, University of Utah, Salt Lake City, Utah 84112 and
**Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109
Manuscript received January 9, 2002
Accepted for publication April 12, 2002
ABSTRACT
We have determined the marker separations (genetic distances) that maximize the probability, or power,
of detecting meiotic recombination deficiency when only a limited number of meiotic progeny can be
assayed. We find that the optimal marker separation is as large as 30100 cM in many cases. Provided the
appropriate marker separation is used, small reductions in recombination potential (as little as 50%) can
be detected by assaying a single interval in as few as 100 progeny. If recombination is uniformly altered

  

Source: Adler, Fred - Department of Mathematics, University of Utah

 

Collections: Environmental Sciences and Ecology