Home

About

Advanced Search

Browse by Discipline

Scientific Societies

E-print Alerts

Add E-prints

E-print Network
FAQHELPSITE MAPCONTACT US


  Advanced Search  

 
Cholinergic Modulation of Pavlovian Fear Conditioning: Effects of Intrahippocampal Scopolamine Infusion
 

Summary: Cholinergic Modulation of Pavlovian Fear Conditioning:
Effects of Intrahippocampal Scopolamine Infusion
Greg D. Gale,* Stephan G. Anagnostaras, and
Michael S. Fanselow
Department of Psychology and Brain Research Institute,
University of California, Los Angeles, California
ABSTRACT: Cholinergic neurotransmission has been implicated in the
acquisition of a variety of tasks, including Pavlovian fear conditioning. To
more precisely define the role of cholinergic modulation in this process,
the effect of site-specific cholinergic antagonism was assessed. Male
Long-Evans rats were implanted with chronic, bilateral cannulae aimed at
the dorsal hippocampus. Infusions of scopolamine hydrobromide (50 g
bilaterally) or phosphate-buffered saline (PBS) were made immediately
prior to a signaled Pavlovian fear conditioning procedure. On consecutive
days following training, all rats were given independent tests assessing
freezing to both the training context and the tone conditional stimulus
(CS). Relative to PBS infused controls, rats that received intrahippocampal
infusions of scopolamine showed a significant attenuation of contextual
freezing but comparable levels of freezing to the tone CS. Neither shock
sensitivity nor general activity levels differed between rats infused with

  

Source: Anagnostaras, Stephan - Neurosciences Program & Department of Psychology, University of California at San Diego

 

Collections: Biology and Medicine