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Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single
 

Summary: Calcium Channel Types with Distinct Presynaptic Localization
Couple Differentially to Transmitter Release in Single
Calyx-Type Synapses
Ling-Gang Wu,1 Ruth E. Westenbroek,2 J. Gerard G. Borst,1 William A. Catterall,2 and Bert Sakmann1
1Abteilung Zellphysiologie, Max-Planck-Institut fuĻ r medizinische Forschung, D-69120 Heidelberg, Germany, and
2Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
We studied how Ca2
influx through different subtypes of Ca2
channels couples to release at a calyx-type terminal in the rat
medial nucleus of the trapezoid body by simultaneously mea-
suring the presynaptic Ca2
influx evoked by a single action
potential and the EPSC. Application of subtype-specific toxins
showed that Ca2
channels of the P/Q-, N-, and R-type con-
trolled glutamate release at a single terminal. The Ca2
influx
through the P/Q-type channels triggered release more effec-
tively than Ca2
influx through N- or R-type channels. We

  

Source: Alford, Simon - Department of Biological Sciences, University of Illinois at Chicago

 

Collections: Biology and Medicine