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Summary: Late onset loss of hippocampal 5-HT and NE is accompanied by
increases in BDNF protein expression in mice co-expressing mutant
APP and PS1
Matthew E. Szapacs, Adam L. Numis, and Anne M. Andrews*
Department of Chemistry and the Huck Institute for Life Sciences, The Pennsylvania State University, University Park, PA 16802-4615, USA
Received 10 September 2003; revised 11 February 2004; accepted 16 April 2004
Available online 28 May 2004
Transgenic mice expressing both mutant amyloid precursor protein
(APPswe) and presenilin-1 (PS1DE9) develop amyloid deposits as early
as 4 months of age and preliminary evidence suggests that this may be
associated with degenerative changes in serotonin axons innervating
the dentate gyrus of the hippocampus. In the present investigation,
which focused on further delineating the effects of amyloid deposition
on hippocampal neurochemistry, decreases in serotonin neurotrans-
mitter levels (À25%) were discovered to be present at 18 months in
APP+
/PS1+
mice, while norepinephrine was reduced in the hippocam-
pus of 12- (À30%) and 18-month-old (À45%) APP+
/PS1+
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