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NEWS AND VIEWS Breaking proteins with mutations: threads and
 

Summary: NEWS AND VIEWS
Breaking proteins with mutations: threads and
thresholds in evolution
Jesse D Bloom1
, Frances H Arnold1
and Claus O Wilke2
1
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA, USA and 2
Section of Integrative Biology and Center for
Computational Biology and Bioinformatics, University of Texas at Austin, Austin, TX, USA
Molecular Systems Biology 30 January 2007; doi:10.1038/msb4100119
A common high school science experiment involves anchoring
one end of a rubber band to a desk and then attaching a small
weight to the other end. The weight stretches the rubber band,
and adding another weight causes the rubber band to dangle
even lower. More weights can be added, and each one pulls the
rubber band a little further towards the floor. Now, instead
imagine attaching the weights to a thread. The thread stretches
only slightly; so the first couple of weights have just a small
effect. But if you add enough weights, the thread suddenly

  

Source: Arnold, Frances H. - Division of Chemistry and Chemical Engineering, California Institute of Technology

 

Collections: Chemistry; Biology and Medicine