Summary: Bennett and Xie (Pain 33: 87, 1988)
Chronic Constrictive Injury Model
From acute to chronic pain state: Long-term telemetric recording
of cortical activity in chronic constriction injury (cci) rats.
A. Apkarian1, M. Baliki1, H. Berra1, O. Calvo2, D. Chialvo1, S. Lavarello1.
1Dept. of Physiology, Northwestern University Medical School, Chicago, IL, 60611, 2 Physics Dept., Universidad de las Islas Baleares, Palma de Mallorca, Spain.
Cortical Dynamics in Response to Painful Thermal Stimuli
Despite many advances, the long-term central nervous
system reorganization associated with neuropathic pain is
In this project we monitor the immediate effects of chronic
constriction nerve injury over pain behavior and brain cortical
electrophysiology in freely moving rats.
Our human brain imaging studies suggest that chronic
neuropathic conditions, consistent with the behavioral
changes, should re-organize cortical electrical dynamics.