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Bacteria as Control Engineers Kyle R. Allison1 and James J. Collins1,2,3,*

Summary: Bacteria as Control Engineers
Kyle R. Allison1 and James J. Collins1,2,3,*
1Howard Hughes Medical Institute, Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston,
MA 02215, USA
2Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
3Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02118, USA
*Correspondence: jcollins@bu.edu
DOI 10.1016/j.molcel.2010.12.025
Bacteria encounter fluctuations in both their external and internal environments, and to manage these condi-
tions, they employ various control mechanisms. In this issue of Molecular Cell, Hart et al. (2011) investigate
how E. coli robustly controls nitrogen assimilation.
Residents of New England are used to
rapidly changing weather conditions--it
can be 70
F and sunny one day and
snowing the next. Most of us rely on engi-
neered control systems to maintain com-
fortable temperatures in our living rooms,
offices, and laboratories, in spite of such
fluctuations outdoors. These control sys-


Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science
Collins, James J. - Wyss Institute for Biologically Inspired Engineering & Department of Biomedical Engineering, Boston University


Collections: Biology and Medicine; Biotechnology; Engineering