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ORIGINAL ARTICLE Xiankai Sun Melinda Wuest Zoltan Kovacs
 

Summary: ORIGINAL ARTICLE
Xiankai Sun Melinda Wuest Zoltan Kovacs
A. Dean Sherry Ramunas Motekaitis Zheng Wang
Arthur E. Martell Michael J. Welch
Carolyn J. Anderson
In vivo behavior of copper-64-labeled methanephosphonate
tetraaza macrocyclic ligands
Received: 13 March 2002 / Accepted: 11 September 2002 / Published online: 11 October 2002
SBIC 2002
Abstract Copper-64 (T1/2=12.7 h; b+
: 0.653 MeV,
17.4%; b
: 0.578 MeV, 39%) is produced in a biomed-
ical cyclotron and has applications in both imaging and
therapy. Macrocyclic chelators are widely used as bi-
functional chelators to bind copper radionuclides to
antibodies and peptides owing to their relatively high
kinetic stability. In this paper, we evaluated three tet-
raaza macrocyclic ligands with two, three, and four
pendant methanephosphonate functional groups. DO2P

  

Source: Anderson, Carolyn J. - Department of Molecular Biology and Pharmacology, Washington University in St. Louis

 

Collections: Biology and Medicine