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ORIGINAL ARTICLE Xiankai Sun Melinda Wuest Zoltan Kovacs

Xiankai Sun Melinda Wuest Zoltan Kovacs
A. Dean Sherry Ramunas Motekaitis Zheng Wang
Arthur E. Martell Michael J. Welch
Carolyn J. Anderson
In vivo behavior of copper-64-labeled methanephosphonate
tetraaza macrocyclic ligands
Received: 13 March 2002 / Accepted: 11 September 2002 / Published online: 11 October 2002
SBIC 2002
Abstract Copper-64 (T1/2=12.7 h; b+
: 0.653 MeV,
17.4%; b
: 0.578 MeV, 39%) is produced in a biomed-
ical cyclotron and has applications in both imaging and
therapy. Macrocyclic chelators are widely used as bi-
functional chelators to bind copper radionuclides to
antibodies and peptides owing to their relatively high
kinetic stability. In this paper, we evaluated three tet-
raaza macrocyclic ligands with two, three, and four
pendant methanephosphonate functional groups. DO2P


Source: Anderson, Carolyn J. - Department of Molecular Biology and Pharmacology, Washington University in St. Louis


Collections: Biology and Medicine