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Cell, Vol. 117, 713720, June 11, 2004, Copyright 2004 by Cell Press Using a Quantitative Blueprint to Reprogram the
 

Summary: Cell, Vol. 117, 713720, June 11, 2004, Copyright 2004 by Cell Press
Using a Quantitative Blueprint to Reprogram the
Dynamics of the Flagella Gene Network
also further activates class 2 promoters, including its
own promoter (Ikebe et al., 1999a, 1999b; Kutsukake et
al., 1990; Liu and Matsumura, 1996). It is not known
Shiraz Kalir and Uri Alon*
Department of Molecular Cell Biology and
Department of Physics of Complex Systems
Weizmann Institute of Science whether FliA can activate class 2 genes in vivo in the
absence of FlhDC, though in vitro FliA can bind RNARehovot, Israel 76100
polymerase to activate some class 2 promoters without
need of FlhDC (Liu and Matsumura, 1996). FliA is inhib-
ited by the anti-sigma factor FlgM, which is expressedSummary
from both class 2 and class 3 promoters. When a func-
tional motor is assembled, FlgM is exported from theDetailed understanding and control of biological net-
works will require a level of description similar to that cell, and FliA becomes active as a transcription factor.
The class 2 promoters are activated in a temporal order,of electronic engineering blueprints. Currently, how-
ever, even the best-studied systems are usually de- with differences on the order of minutes (Laub et al.,
2000; Kalir et al., 2001). This activation order corre-scribed using qualitative arrow diagrams. A quantita-

  

Source: Alon, Uri - Departments of Molecular Cell Biology & Physics of Complex Systems, Weizmann Institute of Science

 

Collections: Biology and Medicine