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Glycine and GABAA Receptor Subunits on Renshaw Cells: Relationship With
 

Summary: Glycine and GABAA Receptor Subunits
on Renshaw Cells: Relationship With
Presynaptic Neurotransmitters and
Postsynaptic Gephyrin Clusters
ERIC J. GEIMAN,1
WEI ZHENG,1
JEAN-MARC FRITSCHY,2
AND
FRANCISCO J. ALVAREZ1*
1
Department of Anatomy, Wright State University, Dayton, Ohio 45435
2
Institute of Pharmacology, University of Zurich, 8057 Zurich, Switzerland
ABSTRACT
Inhibitory synapses with large and gephyrin-rich postsynaptic receptor areas are likely
indicative of higher synaptic strength. We investigated the presynaptic inhibitory neuro-
transmitter content (GABA, glycine, or both) and the presence and subunit composition of
GABAA and glycine postsynaptic receptors in one example of gephyrin-rich synapses to
determine neurochemical characteristics that could also contribute to enhance synaptic
strength. Hence, we analyzed subunit receptor expression in gephyrin patches located on

  

Source: Alvarez, Francisco J. - Department of Neuroscience, Cell Biology, and Physiology, Wright State University

 

Collections: Biology and Medicine