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INFECTION AND IMMUNITY, Jan. 2004, p. 398407 Vol. 72, No. 1 0019-9567/04/$08.00 0 DOI: 10.1128/IAI.72.1.398407.2004

Summary: INFECTION AND IMMUNITY, Jan. 2004, p. 398407 Vol. 72, No. 1
0019-9567/04/$08.00 0 DOI: 10.1128/IAI.72.1.398407.2004
Copyright 2004, American Society for Microbiology. All Rights Reserved.
Both Free-Living and Parasitic Nematodes Induce a Characteristic Th2
Response That Is Dependent on the Presence of Intact Glycans
Salah Tawill, Laetitia Le Goff, Fahimeda Ali, Mark Blaxter, and Judith E. Allen*
Institute of Cell, Animal, and Population Biology, University of Edinburgh,
Edinburgh, United Kingdom
Received 24 July 2003/Returned for modification 3 September 2003/Accepted 8 October 2003
Infection with parasitic nematodes is characterized by the induction of a profound type 2 immune response.
We have studied the role of glycans in the induction of the skewed type 2 response by antigens of the parasitic
nematode Brugia malayi as well as the free-living nematode Caenorhabditis elegans. Lymph node cells from
BALB/c mice immunized with soluble extracts of the two nematodes showed distinct antigen-specific prolifer-
ation and cytokine production; however, both nematodes induced antigen-specific interleukin 4 (IL-4) produc-
tion, demonstrating that the induction of a biased type 2 response is not unique to parasitic nematodes. Sodium
periodate-treated soluble extracts of both nematodes consistently induced significantly less IL-4 production
than the respective mock-treated extracts, indicating that glycans play a critical role in the induction of the Th2
immune response by these nematodes. The glycan-dependent induction of the Th2-potentiating cytokine IL-4
occurs by 72 h postinoculation. Our data suggest that glycan determinants common to nematodes act as
ligands, displaying distinct molecular patterns that trigger the immune system to launch a biased Th2 immune


Source: Allen, Judith - School of Biological Sciences, University of Edinburgh


Collections: Biology and Medicine