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Chem. Res. Toxicol., 2009, 22 (3), 417-418· DOI: 10.1021/tx9000368 · Publication Date (Web): 16 March 2009
Downloaded from http://pubs.acs.org on March 18, 2009
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Food-Borne Toxin Sensitivity
Subtilase cytotoxin (SubAB) is an AB5 toxin produced by
Shiga toxigenic E. coli (STEC) bacteria. AB5 toxins bind to
cognate glycan receptors on target cells via their pen-
tameric B subunits and inflict cellular damage through their
A subunit. SubAB causes gastrointestinal disease in humans
and hemolytic uremic syndrome in mice through SubA-
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