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Mouse Models for Deafness: Lessons for the Human Inner Ear and Hearing Loss
 

Summary: Mouse Models for Deafness: Lessons for the Human
Inner Ear and Hearing Loss
Karen B. Avraham
In the field of hearing research, recent advances
using the mouse as a model for human hearing loss
have brought exciting insights into the molecular
pathways that lead to normal hearing, and into the
mechanisms that are disrupted once a mutation
occurs in one of the critical genes. Inaccessible for
most procedures other than high-resolution com-
puted tomography (CT) scanning or invasive sur-
gery, most studies on the ear in humans can only be
performed postmortem. A major goal in hearing
research is to gain a full understanding of how a
sound is heard at the molecular level, so that diag-
nostic and eventually therapeutic interventions can
be developed that can treat the diseased inner ear
before permanent damage has occurred, such as
hair cell loss. The mouse, with its advantages of
short gestation time, ease of selective matings, and

  

Source: Avraham, Karen - Department of Human Genetics and Molecular Medicine, Tel Aviv University

 

Collections: Biology and Medicine