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Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule
 

Summary: Virtual Ligand Screening of the p300/CBP Histone
Acetyltransferase: Identification of a Selective Small Molecule
Inhibitor
Erin M. Bowersa, Gai Yanb, Chandrani Mukherjeea, Andrew Orryc, Ling Wanga, Marc A.
Holberta, Nicholas T. Crumpd, Catherine A. Hazzalind, Glen Liszczake, Hua Yuane, Cecilia
Laroccab, S. Adrian Saldanhaf, Ruben Abagyang, Yan Suna, David J. Meyersa, Ronen
Marmorsteine,h, Louis C. Mahadevand, Rhoda M. Alanib,*, and Philip A. Colea,b,*
aDepartment of Pharmacology and Molecular Sciences, Johns Hopkins University School of
Medicine, Baltimore, MD 21205
bDepartment of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21205
cMolsoft LLC, La Jolla, CA 92037
dNuclear Signalling Laboratory, Department of Biochemistry, Oxford University, Oxford, UK, OX1
3QU
eProgram in Gene Expression and Regulation, The Wistar Institute, Philadelphia, PA 19104
fThe Scripps Research Institute, Jupiter, Florida 33458
gUniv. of California, San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, La Jolla,
CA, 92093
hDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA 19104
Summary
The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many

  

Source: Abagyan, Ruben - School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego

 

Collections: Biology and Medicine