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Chemical Heterogeneity of the Living Human Brain: A Proton MR Spectroscopy Study on the Effects of Sex, Age, and Brain Region
 

Summary: Chemical Heterogeneity of the Living Human Brain: A Proton MR
Spectroscopy Study on the Effects of Sex, Age, and Brain Region
Igor D. Grachev1
and A. Vania Apkarian
Department of Neurosurgery and Department of Neuroscience and Physiology,
SUNY Upstate Medical University, Syracuse, New York 13210
Received August 17, 1999
Brain chemistry was compared between 19 male and
female normal volunteers in the age group 1931
years, across six brain regions and nine metabolites
using in vivo proton magnetic resonance spectros-
copy. The relative concentrations of N-acetyl aspar-
tate, choline, glutamate, glutamine, GABA, inositol,
glucose, and lactate were measured relative to creat-
ine within 8-cm3
brain voxels. These measurements
were performed in six brain regions: thalamus and
cingulate, insula, sensorimotor , dorsolateral prefron-
tal , and orbital frontal cortices in the left hemisphere.
Total metabolite concentration was highest in pre-

  

Source: Apkarian, A. Vania - Department of Physiology, Northwestern University

 

Collections: Biology and Medicine