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Neuron, Vol. 47, 307320, July 21, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.neuron.2005.06.006 Prefrontal Cortex Activity Related to
 

Summary: Neuron, Vol. 47, 307320, July 21, 2005, Copyright 2005 by Elsevier Inc. DOI 10.1016/j.neuron.2005.06.006
Prefrontal Cortex Activity Related to
Abstract Response Strategies
Aldo Genovesio, Peter J. Brasted, Andrew R. Mitz, as they learned new stimulus-response mappings,
nearly doubling their reward rate in the earliest phasesand Steven P. Wise*
Laboratory of Systems Neuroscience of learning. Other monkeys have adopted one or nei-
ther strategy.National Institute of Mental Health
Bethesda, Maryland 20892 Parts of the prefrontal cortex (PF) play a necessary
role in the implementation of these and other strategies
(Bussey et al., 2001), yet little is known about their neu-
Summary ral basis. PF has been viewed as a neural substrate for
rules and strategies in humans (Brass et al., 2003; Bunge,
Many monkeys adopt abstract response strategies as 2005; Bunge et al., 2003; Owen et al., 1990, 1996; Rob-
they learn to map visual symbols to responses by trial bins, 2000; Rushworth et al., 2002) and monkeys (Collins
and error. According to the repeat-stay strategy, if a et al., 1998; Gaffan et al., 2002), and previous neuro-
symbol repeats from a previous, successful trial, the physiological studies of PF have found rule- and strat-
monkeys should stay with their most recent response egy-related activity (Asaad et al., 2000; Barraclough et
choice. According to the change-shift strategy, if the al., 2004; Fuster et al., 2000; Hoshi et al., 2000; Wallis
symbol changes, the monkeys should shift to a dif- and Miller, 2003b; White and Wise, 1999). However,
ferent choice. We recorded the activity of prefrontal there have been no neurophysiological studies of the

  

Source: Andrzejak, Ralph Gregor - Departament de Tecnologia, Universitat Pompeu Fabra

 

Collections: Computer Technologies and Information Sciences