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Behavioral/Systems/Cognitive Frequency-Selective Coding of Translation and Tilt in

Summary: Behavioral/Systems/Cognitive
Frequency-Selective Coding of Translation and Tilt in
Macaque Cerebellar Nodulus and Uvula
Tatyana Yakusheva,1
Pablo M. Blazquez,2
and Dora E. Angelaki1
Departments of 1
Neurobiology and 2
Otolaryngology, Washington University School of Medicine, St. Louis, Missouri 63110
Spatial orientation depends critically on the brain's ability to segregate linear acceleration signals arising from otolith afferents into
frequencies. The cerebellar nodulus/uvula (NU) has been shown to participate in this computation, although its exact role remains
unclear. Here, we show that NU simple spike (SS) responses also exhibit a frequency dependent selectivity to self-motion (translation)
and spatial orientation (tilt). At 0.5 Hz, Purkinje cells encode three-dimensional translation and only weakly modulate during pitch and
rolltilt(0.4 0.05spikes/s//s).Butthisabilitytoselectivelysignaltranslationovertiltiscompromisedatlowerfrequencies,suchthatat
0.05 Hz tilt response gains average 2.0 0.3 spikes/s//s. We show that such frequency-dependent properties are attributable to an
incomplete cancellation of otolith-driven SS responses during tilt by a canal-driven signal coding angular position with a sensitivity of
3.9 0.3spikes/s/.Thisincompletecancellationisbroughtaboutbecauseotolith-drivenSSresponsesarealsopartiallyintegrated,thus
an internal neural representation of similar frequency dependencies seen in behavior.


Source: Angelaki, Dora - Department of Anatomy and Neurobiology, Washington University in St. Louis


Collections: Biology and Medicine